For Healthcare Professionals. Indole-3-Carbinol (I3C) is a phytochemical derived from the breakdown of glucosinolates found in cruciferous vegetables including Brussels sprouts, kale, broccoli, cabbage, and cauliflower .What is the highest dose of indole-3-carbinol?
Dosing considerations for Indole-3-carbinol. For treating abnormal cells on the surface of the cervix (cervical dysplasia): 200-400 mg per day has been used. However, 200 mg seems to be as effective as the higher dose.Is indindole-3-carbinol safe to take?
Indole-3-carbinol is POSSIBLY SAFE for most people when taken by mouth as a medicine under proper medical supervision. Doses up to 400 mg daily have been used safely for 3-76 months. It can cause side effects such as skin rashes and diarrhea.How does indole-3-carbinol inhibit tumorigenicity of hepatocellular carcinoma cells?
Wang X, He H, Lu Y, et al. Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensin homolog. Biochim Biophys Acta. Jan 2015;1853 (1):244-253.