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Indole-3-carbinol is formed from a substance called glucobrassicin found in vegetables such as broccoli, Brussels sprouts, cabbage, collards, cauliflower, kale, mustard greens, turnips, and rutabagas. Indole-3-carbinol is formed when these vegetables are cut, chewed or cooked.How does indole-3-carbinol interact with NEDD4?
In a second study Kundu et al. showed that in melanoma cells where PTEN is downregulated, indole-3-carbinol directly interacts with NEDD4 1 to prevent PTEN ubiquitination and subsequent proteasomal degradation. This results in stabilization of PTEN and inhibition of proliferation by downstream AKT signaling.Is indindole-3-carbinol safe to take?
Indole-3-carbinol is POSSIBLY SAFE for most people when taken by mouth as a medicine under proper medical supervision. Doses up to 400 mg daily have been used safely for 3-76 months. It can cause side effects such as skin rashes and diarrhea.Can indole-3-carbinol be used long term for papillomatosis?
Recurrent respiratory papillomatosis. There is some evidence that long-term use of indole-3-carbinol might reduce tumor (papilloma) growth in people with recurrent respiratory papillomatosis. Systemic lupus erythematosus (SLE).